Citizens of Quahog are invited by actor James Woods to his stately mansion on a remote island. While there, a series of murders occur, and the group struggles to determine who committed the mysterious acts, before ultimately attempting to escape from the island, and avoid being murdered themselves.

Brian, an adamant liberal, decides to confront conservative radio talk show host Rush Limbaugh at a book signing in Quahog and ultimately ends up having a political change of heart when Limbaugh convinces him to read his latest novel. Brian eventually decides to become a devoted member of the Republican Party, and soon begins criticizing liberals. This leads Brian to become roommates with Limbaugh, and begins following him everywhere, before Rush convinces Brian of his true political convictions.

Peter discovers his father-in-law, Carter Pewterschmidt, having an affair. Deciding to blackmail Carter, Peter begins taking advantage of his father-in-law's wealth, before accidentally spilling the beans to his wife's mother. Soon after, Peter becomes Carter's wingman, and helps him in rediscovering his bachelorhood.

As Halloween arrives on Spooner Street, Peter and Joe prepare a series of unpleasant Halloween pranks for unsuspecting family, friends, and neighbors. Stewie and Brian go trick or treating, and Meg attends her high school's Halloween dance to "kill" everyone who has bullied her in the past.

Lois competes in the fight of the century with Peter as her manager.

Stewie becomes Brian's writing manager and his book becomes a best seller. Bill Maher (guest star) has a talk with Brian. Lois and Peter start sleeping in separate beds.

Double header (Episode 907 - 908) Brian and Stewie go on an adventure to the North Pole to find and kill Santa Claus.

Peter, after drinking kerosene, suffers from immediate kidney failure. In need of a replacement kidney, Peter is unable to locate a match, until it is discovered that his anthropomorphic dog Brian is a match, but would require the donation of both his kidneys. Meanwhile, Chris is instructed by his English teacher to write an essay about hope, in preparation of United States President Barack Obama's appearance at their school. Unable to write anything inspiring, he decides to plagiarize his sister, Meg, instead.

Lois becomes friends with Joyce Kinney, the new television news co-anchor, but Kinney eventually airs a news story on Lois portraying her in a negative way.

Brian and Peter are required to attend a 12-step program to deal with their drinking problems, and Death gives Peter a glimpse of what life would be like without alcohol.

On the search to find Chris a new hobby, he along with his father, begin collecting stamps and drinking, but Chris is amazed by neither. He soon discovers a puppet shop, however, with the shop's owner, Franz Gutentag, quickly befriending him.

Meg offers to check on her neighbor, Joe Swanson, while his wife, Bonnie, is out of town. Meanwhile, Stewie accidentally creates an evil clone of himself.

The Griffin family decides to switch roles in order to teach each other a lesson about responsibility, with Peter and Lois becoming the children, and Chris and Meg becoming the parents of the household. They each discover hardships in their new roles, however, as the switch causes a strain on the family's relationship, and eventually resulting in the ultimate consequence.

Peter loses his favorite shirt while Brian and Quagmire compete for the affections of each other's old flames.

Carol Pewterschmidt, Lois' sister, turns to the Griffins after her ninth husband ended their relationship. She eventually goes on a date with Mayor Adam West and seeks to marry him, much to Lois' doubt given her overprotective nature for Carol.

Stewie and Brian go back in time to stop Stewie's half-brother Bertram from killing Leonardo da Vinci, which would erase Stewie from the universe.

Lois and Bonnie take a trip to Paris, but Bonnie crosses the line with a smooth-talking womanizer, and has to explain everything to Joe. Meanwhile, Peter homeschools Chris and Meg using odd methods.

The "Star Wars" trilogy ("Family Guy"-style) concludes. But first, Luke Skywalker (Chris) and Princess Leia (Lois) must travel to Tatooine to free Han Solo (Peter) by infiltrating the wretched stronghold of Jabba the Hutt (Joe), the galaxy’s most loathsome and dreadful gangster. Once reunited, the Rebels team up with a tribe of Ewoks to combat the Imperial forces on the forest moon of Endor. Meanwhile the Emperor (Carter Pewterschmidt) and Darth Vader (Stewie) conspire to turn Luke to the dark side, and young Skywalker is determined to rekindle the spirit of the Jedi within his father. The Galactic Civil War has never been more outrageous, as the Rebel forces gather to attack the seemingly defenseless and incomplete second Death Star in the battle that will determine the fate of the galaxy.